nephrology tubulointerstitial 1 12

• related: Nephrology
• tags: #nephrology

AIN

• vasculature, glomerulus spared
• causes
  • allergy/drug induced: 70%
  • infections: acute/chronic pyelo
  • autoimmune: sjogren, lupus, sarcoid
  • idiopathic
• Sx
  • fever, rash, eosinophilia
  • renal failure
• labs
  • na wasting, acidification, normal to mildly increased proteinuria
  • WBC, hyperkalemia, hypokalemia
• Urine: WBC, WBC casts, mild RBC, mild proteinuria, maybe eosinophils

Drugs

• beta lactam
• sulfonamides
• bactrim
• diuretics: sulfa drugs
• rifampin
• quinolones
• nsaids
• PPI
• 5-aminosalicylates

• hep B: MPGN
• hep C: rpgn
• fanconi: glucosuria with normal serum glucose

Infuction induced AIN

• any infection can cause AIN
• most commonly chronic UTI/pyelonephritis
• BK nephropathy: reactivation in transplant patients